Research
For a complete list of publications, go to my Google Scholar page. Code and data for papers are published as supplementary information and/or on Github.
IMPACT OF LAND USE CHANGE ON INFECTIOUS DISEASE DYNAMICS
Land use change is a common feature of landscapes globally and has been shown to impact disease transmission. Changes in prevalence of infectious disease (both increases and decreases) have been associated with land use change in both specialist and generalist parasites. These changes in disease burden are driven by a network of interactions, and understanding general patterns across the diversity of land use change, host communities, and pathogen life histories has presented an immense challenge.
My research focuses on understanding mechanisms driving changes in host communities and the cascading implications for parasite transmission. I am particularly interested in vector-borne diseases that have endemic and zoonotic transmission cycles.
Relevant Publications
Becker, D, A Washburne, CL Faust, EA Mordecai, and R Plowright. 2019. The problem of scale in the prediction and management of pathogen spillover. Philos T R Soc B. 374: 1782. (doi: 10.1098/rstb.2019.0014)
Becker, D, A Washburne, CL Faust, J Pulliam, E Mordecai, J Lloyd-Smith, and R Plowright. 2019. Dynamic and integrative approaches to understanding pathogen spillover. Philos T R Soc B. 374: 1782
Borremans, B, CL Faust, KR Manlove, SH Sokolow, and JO Lloyd-Smith. 2019. Parasite spillover near ecosystem boundaries: mechanisms and theory. Philos T R Soc B. 374: 1782
Faust, CL, HI McCallum, LSP Bloomfield, NL Gottdenker, TR Gillespie, CJ Torney, AP Dobson, and RK Plowright. 2018. Pathogen spillover during land conversion. Ecology Letters. 21(4):471-483.
Faust, CL, Dobson, A. P., Gottdenker, N., Bloomfield, L. S.P., McCallum, H. I., Gillespie, T. R., Diuk-Wasser, M. and Plowright, R. K. 2017. Null expectations for disease dynamics in shrinking habitat: dilution or amplification? Phil Trans Roy Soc B: Biol Sci, 372(1722), 20160173.(doi:10.1098/rstb.2016.0173)
Gottdenker, N, D Streicker, C Faust, and R Carroll. 2014. Anthropogenic Land Use Change and Infectious Diseases: A Review of the Evidence. EcoHealth. 11(4):619-632. PDF.
Roy, AH, CL Faust, MC Freeman, and JL Meyer. 2005. Reach-scale effects of riparian forest cover on urban stream ecosystems. Canadian Journal of Fisheries and Aquatic Sciences. 62: 2312-2329. PDF.
INTEGRATING POPULATION GENETICS AND EVOLUTION INTO EPIDEMIOLOGY
Relevant Publications
Trienekens, SCM, CL Faust, K Meginnis, L Pickering, O Ericsson. 2020. Impacts of host gender on Schistosoma mansoni risk in rural Uganda—A mixed-methods approach. PLoS Negl Trop Dis 14 (5): e0008266. Open Access.
Greischar, MA, HK Alexander, F Bashey, AI Bento, A Bhattacharya, M Bushman, LM Childs, DR Daversa, T Day, CL Faust, ME Gallagher, S Gandon, CK Glidden, FW Halliday, KA Hanley, T Kamiya, AF Read, P Schwabl, AR Sweeny, AT Tate, RN Thompson, N Wale, HJ Wearing, PJ Yeh, N Mideo. 2020. Evolutionary consequences of feedbacks between within-host competition and disease control. Evol Med & Pub Heal. 1:30-34
Faust, CL, M Crotti, A Moses, D Oguttu, A Wamboko, M Adriko, EK Adekanle, N Kabatereine, EM Tukahebwa, AJ Norton, CM Gower, JP Webster and PHL Lamberton. 2019. Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda. Parasites & Vectors. 12:607.
*Viana, M, *CL Faust, DT Haydon, JP Webster, and PHL Lamberton. 2017. The effects of sub-curative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni. Evol Appl. 11: 488–500. *joint first authors
ECOLOGY AND TRANSMISSION OF MULTI-HOST PATHOGENS
Relevant Publications
Lamberton, PHL, CL Faust, and JP Webster. 2017. Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study. Infect Dis Poverty. 6:110. Open Access.
Faust, C and A. Dobson. Primate malarias: diversity, distribution and implications for zoonotic Plasmodium. OneHealth. 1:66-75. Open Access.
Siregar, J.E., C. Faust, L. Murdiyarso, L. Rosmanah, U. Saepuloh, A. P. Dobson, and D. Iskandriati. Noninvasive surveillance for Plasmodium in reservoir macaque species. Malaria Journal. 14:404. Open Access.
White, GB, and C Faust. 2013. Medical Acarology and Entomology. In: J Farrar, P Hotez, T Junghanass, G Kang, D Lalloo, and NJ White (eds). Manson’s Tropical Disease. Elsevier Health Science: London. pp. 1258-1278.
Faust, C, D Stallknecht, D Swayne, and J Brown. 2009. Filter-Feeding Bivalves Can Remove Avian Influenza Viruses from Water and Reduce Infectivity. Proceedings of the Royal Society B. 276: 3727-3735. Open Access.
PATHOGEN SELECTION IN WILD POPULATIONS
A wealth of theory and experimental and natural microbial population studies highlight the importance of host adaptation in the evolution of parasites. We often think of pathogens, with their short-life span, as the more adaptable organism in a host-parasite interaction, however hosts can, and do, adapt to infection with specific pathogens. Variation in host populations has implication for transmission of pathogens and imposes selection on pathogens. My research focuses on variation in hemoglobin of wild populations of birds and macaques to understand implications for malaria transmission.
Relevant Publications
[PrePrint] Faust, CL, F Rangkuti, SG Preston, A Boyd, P Flammer, B Bia, NJ Rose, FB Piel, AL Smith, AP Dobson, S Gupta, BS Penman. Alpha globin variation in the long-tailed macaque suggests malaria selection. bioRxiv (doi: 10.1101/2020.10.21.344853)
DATA-DRIVEN POLICY RECOMMENDATIONS FOR THE MANAGEMENT OF DISEASE
Relevant Publications
Faust, CL, K Brunker, S Ajambo, M Ryan, A Moses, C Rowel, RM Wangoola, EM Wampande, A Guma, M Adriko, PHL Lamberton, EM Tukahebwa, A Mugenyi, C Waiswa. 2020. Harnessing technology and portability to conduct molecular epidemiology of endemic pathogens in resource-limited settings. Trans Roy Soc Trop Med Hyg. Online Early. Open Access.
Faust, CL, DMN Osakunor, JA Downs, S Kayuni, JR Stothard, PHL Lamberton, J Reinhard-Rupp, D Rollinson. 2020. Schistosomiasis control: leave no age group behind. Trends Parasitol. 36(7): 582-591. Open Access.
*Adriko, M, *CL Faust, LV Carruthers, A Moses, EM Tukahebwa, and PHL Lamberton. 2018. Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to absence of treatment opportunities rather than systematic non-compliance. Trop Med Infect Dis. 3(4): 111. Open Access. *joint first authors
Faust, C, J Zelner, P Brasseur, M Vaillant, M Badiane, M Cisse, B Grenfell, and P Olliaro. 2015. Assessing drivers of full adoption of Test and Treat policy for malaria in Senegal. AJTMH. 93(1):159-167. Open Access.